Corpus ID: 34317444

Protective effects of ibuprofen and methylprednisolone on chemotactic factor-induced transcutaneous hypoxia.

@article{Maderazo1986ProtectiveEO,
  title={Protective effects of ibuprofen and methylprednisolone on chemotactic factor-induced transcutaneous hypoxia.},
  author={Eufronio G. Maderazo and Steven P. Breaux and Charles L. Woronick},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1986},
  volume={238 2},
  pages={
          453-6
        }
}
  • Eufronio G. Maderazo, Steven P. Breaux, Charles L. Woronick
  • Published in
    The Journal of pharmacology…
    1986
  • Chemistry, Medicine
  • We showed previously in vitro that ibuprofen, a nonsteroidal anti-inflammatory agent, at concentrations easily achievable in blood, inhibits polymorphonuclear leukocyte cell swelling and aggregation in response to chemotactic factor stimulation. To confirm this in vivo, we studied the ability of ibuprofen i.v. pretreatment to reverse the transcutaneous hypoxia induced by i.v. infusion of 1 nmol/kg of formyl-methionyl-leucyl-phenylalanine. This effect was compared with that of methylprednisolone… CONTINUE READING

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