Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairment

Abstract

The development of cognitive impairment in sepsis is associated with neurotoxic effects caused by oxidative stress. We have assessed the effects of acute and extended administration of guanosine (GUA) on brain oxidative stress parameters and cognitive impairment in rats submitted to sepsis by cecal ligation and perforation (CLP). To achieve this goal, male… (More)
DOI: 10.1016/j.bbi.2012.03.007

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@article{Petronilho2012ProtectiveEO, title={Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairment}, author={Fabricia Petronilho and Susane Raquel P{\'e}rico and Francieli Vuolo and Francielle Gonçalves Mina and Larissa Constantino and Clarissa Martinelli Comim and J. Quevedo and Diogo Onofre Souza and Felipe Dal-Pizzol}, journal={Brain, Behavior, and Immunity}, year={2012}, volume={26}, pages={904-910} }