Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury.

@article{Wang2002ProtectiveEO,
  title={Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury.},
  author={Yun Wang and Chun Fang Chang and Mois{\'e}s Morales and Y H Chiang and John Hoffer},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={962},
  pages={423-37}
}
Glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been shown to have trophic activity on dopaminergic neurons. Recent studies indicate that GDNF can protect the cerebral hemispheres from damage induced by middle cerebral arterial ligation. We found that such neuroprotective effects are mediated through specific GDNF receptor alpha-1 (GFRalpha1). Animals with a deficiency in GFRalpha-1 have less GDNF-induced… CONTINUE READING

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