Protective effects of fluvoxamine against ischemia/reperfusion injury in isolated, perfused guinea-pig hearts.

@article{Muto2014ProtectiveEO,
  title={Protective effects of fluvoxamine against ischemia/reperfusion injury in isolated, perfused guinea-pig hearts.},
  author={Tatsuya Muto and Haruki Usuda and Aya Yamamura and Koji Yoshida and Ai Ohashi and Kumiko Mitsui-Saitoh and Junichi Sakai and Yumi Sugimoto and Hideki Mizutani and Tsunemasa Nonogaki and Yoshihiro Hotta},
  journal={Biological & pharmaceutical bulletin},
  year={2014},
  volume={37 5},
  pages={731-9}
}
Serotonin (5-hydroxytryptamine; 5-HT) is known to be activated during ischemia-reperfusion and triggers contractile dysfunction and pathological apoptosis. Here, the beneficial effects of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine was demonstrated on ischemia-reperfusion injury in guinea-pig hearts perfused using the Langendorff technique… CONTINUE READING