Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway.

@article{Zhang2017ProtectiveEO,
  title={Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway.},
  author={Yimeng Zhang and Xufeng Tao and Lianhong Yin and Lina Xu and Youwei Xu and Yan Qi and Xu Han and Shasha Song and Yan-yan Zhao and Yuan Lin and Kexin Liu and Jinyong Peng},
  journal={British journal of pharmacology},
  year={2017},
  volume={174 15},
  pages={
          2512-2527
        }
}
BACKGROUND AND PURPOSE Dioscin exhibits a range of pharmacological actions but little is known of its effects on cisplatin (CDDP)-induced nephrotoxicity. Here, we have assessed the effects and the possible mechanisms of dioscin against CDDP-induced nephrotoxicity. EXPERIMENTAL APPROACH We used an in vivo model of CDDP-induced nephrotoxicity in rats and mice and, in vitro, cultures of NRK-52E and HK-2 cells. The dual luciferase reporter assay was used to demonstrate modulation, by dioscin, of… CONTINUE READING