Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats.

@article{Punithavathi2003ProtectiveEO,
  title={Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats.},
  author={Durairaj Punithavathi and Narayanan Venkatesan and Mary Babu},
  journal={British journal of pharmacology},
  year={2003},
  volume={139 7},
  pages={
          1342-50
        }
}
(1) We have studied whether curcumin prevents amiodarone-induced lung fibrosis in rats. Intratracheal instillation of amiodarone (6.25 mg kg(-1) on days 0 and 2, and then killed on day 3, day 5, week 1, week 3 and week 5 after amiodarone administration) induced increases in total protein and lactate dehydrogenase (LDH) activity on days 3 and 5 in bronchoalveolar lavage fluid (BALF). Total cell counts, alveolar macrophages, neutrophils and eosinophils recovered by BAL, and lung myeloperoxidase… CONTINUE READING

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