Protective effects of common anthocyanidins against genotoxic damage induced by chemotherapeutic drugs in mice.

@article{Khandelwal2014ProtectiveEO,
  title={Protective effects of common anthocyanidins against genotoxic damage induced by chemotherapeutic drugs in mice.},
  author={Nidhi Khandelwal and Suresh K. Abraham},
  journal={Planta medica},
  year={2014},
  volume={80 15},
  pages={
          1278-83
        }
}
Experiments were performed to assess in mice the inhibitory effects of the anthocyanidins cyanidin, delphinidin, malvidin, and pelargonidin on genotoxic damage induced by the anticancer drugs cyclophosphamide, procarbazine, and cisplatin. Each anthocyanidin was administered 30 min before injecting the drug, and genotoxicity was assessed by measuring micronucleated polychromatic erythrocytes in bone marrow cells. In addition, we monitored the effect of anthocyanidins on apoptosis induced by… Expand
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