Protective effects of cardiac resynchronization therapy in a canine model with experimental heart failure by improving mitochondrial function: a mitochondrial proteomics study

@article{Gong2020ProtectiveEO,
  title={Protective effects of cardiac resynchronization therapy in a canine model with experimental heart failure by improving mitochondrial function: a mitochondrial proteomics study},
  author={X. Gong and Zi-qing Yu and Zheyong Huang and Liqi Xie and Nianwei Zhou and J. Wang and Yixiu Liang and S. Qin and Zhenning Nie and Liming Wei and Z. Li and S. Wang and Yangang Su and J. Ge},
  journal={Journal of Interventional Cardiac Electrophysiology},
  year={2020},
  pages={1-13}
}
  • X. Gong, Zi-qing Yu, +11 authors J. Ge
  • Published 2020
  • Medicine
  • Journal of Interventional Cardiac Electrophysiology
  • Purpose Cardiac resynchronization therapy (CRT) is well acknowledged as an effective treatment for dyssynchronous heart failure. However, the molecular mechanism is unclear to date. Mitochondrial dysfunction and impaired energetic metabolism are two important mechanisms that lead to heart failure. Therefore, we aim to screen the changes of mitochondria-associated proteins and signaling pathways involved in heart failure and CRT treatment. Methods A total of 24 beagle dogs were randomly assigned… CONTINUE READING

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