Protective effects of calcium antagonists in human renal transplantation.

  title={Protective effects of calcium antagonists in human renal transplantation.},
  author={Hans Helmut Neumayer and Ulrich Kunzendorf and Matthias Schreiber},
  journal={Kidney international. Supplement},
To test the hypothesis that calcium antagonists decrease the incidence and severity of delayed graft function, we conducted three separate, prospective, randomized trials. In these trials, we investigated the effects of diltiazem and those of the prostacyclin analogue iloprost. In the first study, 22 control patients and 20 diltiazem patients received grafts perfused with either vehicle or diltiazem 20 mg/liter in the Euro-Collins solution. Subsequently, the diltiazem subjects were given the… CONTINUE READING