Protective effects of bupivacaine against kainic acid-induced seizure and neuronal cell death in the rat hippocampus.

@article{Chiu2015ProtectiveEO,
  title={Protective effects of bupivacaine against kainic acid-induced seizure and neuronal cell death in the rat hippocampus.},
  author={Kuan Ming Chiu and Chia Chan Wu and Ming Wang and Ming Yi Lee and Su Jane Wang},
  journal={Biological & pharmaceutical bulletin},
  year={2015},
  volume={38 4},
  pages={522-30}
}
The excessive release of glutamate is a critical element in the neuropathology of epilepsy, and bupivacaine, a local anesthetic agent, has been shown to inhibit the release of glutamate in rat cerebrocortical nerve terminals. This study investigated whether bupivacaine produces antiseizure and antiexcitotoxic effects using a kainic acid (KA) rat model, an animal model used for temporal lobe epilepsy, and excitotoxic neurodegeneration experiments. The results showed that administering… CONTINUE READING
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