Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells.

@article{Hsieh2007ProtectiveEO,
  title={Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells.},
  author={Yih-shou Hsieh and W H Kuo and Ta-Wei Lin and H Chang and Teseng-His Lin and Pei-Ni Chen and S X Chu},
  journal={Journal of agricultural and food chemistry},
  year={2007},
  volume={55 25},
  pages={10437-45}
}
The oxidative modification of low-density lipoprotein (LDL) is thought to have a central role in the pathogenesis of atherogenesis. Berberine, a natural constituent of plants of the genera Coptis and Berberis, has several anti-inflammation and anticancer biological effects. However, its protective effects on LDL oxidation and endothelial injury induced by oxLDL remain unclear. In this study, we evaluated the antioxidative activity of berberine and how berberine rescues human umbilical vein… CONTINUE READING

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