Protective effects of aspirin in endotoxic shock.

  title={Protective effects of aspirin in endotoxic shock.},
  author={Perry V. Halushka and W. C. Wise and James A. Cook},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={218 2},
Endotoxic shock is associated with increased metabolism of arachidonic acid to thromboxanes (TX) and prostaglandins (PG). This study assessed the effects of varied doses of aspirin, an inhibitor of arachidonic acid metabolism, on Salmonella enteriditis endotoxin (20 mg/kg)-induced mortality, plasma levels of arachidonate metabolites and other pathophysiological sequelae in Long-Evans rats. Aspirin, in doses of 3.75, 15 an 30 mg/kg, given 30 min before endotoxin significantly (P less than .01… CONTINUE READING