Protective effects of an aptamer inhibitor of neutrophil elastase in lung inflammatory injury

@article{Bless1997ProtectiveEO,
  title={Protective effects of an aptamer inhibitor of neutrophil elastase in lung inflammatory injury},
  author={Nicolas M. Bless and Drew Smith and Josephine Charlton and Boris J. Czermak and Hagen Schmal and Hans Peter Friedl and Peter A. Ward},
  journal={Current Biology},
  year={1997},
  volume={7},
  pages={877-880}
}
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68 Citations
Background Citations
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Methods Citations
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68 Citations

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It is suggested that NETs form in the lungs duringTRALI, contribute to the disease process, and thus could be targeted to prevent or treat TRALI.
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References

SHOWING 1-10 OF 26 REFERENCES
The role of neutrophil elastase in chronic inflammation.
  • G. Döring
  • Medicine, Biology
    American journal of respiratory and critical care medicine
  • 1994
TLDR
Besides a number of harmful effects of neutrophil elastase in inflammation, the latter mechanism, although considerably impairing phagocytosis, may be beneficial particularly in the light of persistent bacterial pathogens in the human lung affected by cystic fibrosis.
In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2.
TLDR
In vivo rat model data support a critical role for neutrophil-derived proteinases in acute lung damage in vivo and identify recombinant human secretory leukoproteinase and recombinanthuman tissue inhibitor of metalloproteinases 2 as potentially efficacious interventions in inflammatory disease states.
Adverse effects of neutrophils on the lung.
  • J. Gadek
  • Medicine, Biology
    The American journal of medicine
  • 1992
Elastin decreases the efficiency of neutrophil elastase inhibitors.
  • M. Padrines, J. Bieth
  • Biology, Chemistry
    American journal of respiratory cell and molecular biology
  • 1991
TLDR
It is concluded that association rate constants of irreversible inhibitors and Ki values of reversible ones may be measured accurately using elastin as a substrate and not those determined with synthetic substrates should be used to decide whether a given inhibitor is potent enough to be a physiologic antielastase or a potential antiElastase drug.
Highly potent irreversible inhibitors of neutrophil elastase generated by selection from a randomized DNA-valine phosphonate library.
TLDR
The analysis shows that this use of a chirally resolved valyl phosphonate results in selection of much more potent inhibitors and that these inhibitors specifically potentiate a single enantiomeric form of the phosphonates.
Tissue injury caused by deposition of immune complexes is L-arginine dependent.
TLDR
The arginine analogue, NG-monomethyl-L-arginine (N-MeArg), which blocks NO, protects against immune complex-induced vascular injury in rats and suggests that in vivo metabolic products of L- arginine, such as NO(.), are directly or indirectly linked to immunecomplex-induced tissue injury.
Role of Antileukoprotease in the Human Lung
TLDR
The biochemical characteristics of ALP and its potential role in the lung under normal and inflammatory conditions are focused on.
In vitro selection of RNA-based irreversible inhibitors of human neutrophil elastase.
Role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in acute lung injury in rats.
TLDR
It is suggested that rat MIP-1 alpha plays an important role in the development of lung injury in these neutrophil-dependent models and seems to be related to production of TNF-alpha, which in turn up-regulates vascular adhesion molecules required for neutrophils influx.
Tissue destruction by neutrophils.
  • S. Weiss
  • Medicine, Biology
    The New England journal of medicine
  • 1989
WITH increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive events in inflammatory diseases ranging from rheumatoid arthritis and myocardial reperfusion…
...
...