Protective effects of alpha lipoic acid versus N-acetylcysteine on ifosfamide-induced nephrotoxicity

@article{Elsisi2015ProtectiveEO,
  title={Protective effects of alpha lipoic acid versus N-acetylcysteine on ifosfamide-induced nephrotoxicity},
  author={Alaa El-din El-sisi and Magda E El-Syaad and Karima el-Desoky and EA Moussa},
  journal={Toxicology and Industrial Health},
  year={2015},
  volume={31},
  pages={107 - 97}
}
Ifosfamide (IFO) is a highly effective chemotherapeutic agent for treating a variety of pediatric solid tumors. However, its use is limited due to its serious side effect on kidneys. The side-chain oxidation of IFO in renal tubular cells produces a reactive toxic metabolite that is believed to be responsible for its nephrotoxic effect. Therefore, this study was carried out to investigate the possible underlying mechanisms that may be involved in IFO-induced nephrotoxicity, including free… 
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