Protective effects of adenosine in the reversibly injured heart.

@article{Lasley1995ProtectiveEO,
  title={Protective effects of adenosine in the reversibly injured heart.},
  author={Robert D. Lasley and Robert M. Mentzer},
  journal={The Annals of thoracic surgery},
  year={1995},
  volume={60 3},
  pages={
          843-6
        }
}
BACKGROUND There is substantial evidence that the nucleoside adenosine reduces postischemic ventricular dysfunction (ie, myocardial stunning). Studies performed in our laboratory have attempted to address the mechanism of adenosine-mediated protection of the reversibly injured heart. METHODS Experiments were performed in isolated perfused rat and rabbit hearts and in in situ canine and porcine preparations. The role of adenosine A1 receptors was assessed by using adenosine A1 receptor… CONTINUE READING
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