Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.

Abstract

Extracellular regulated kinases (ERK1/2) and c-Jun N-terminal Kinases (JNK), are generally considered to play a key role in signal transduction pathways activated by a wide range of stimuli. We studied the effects of SP600125, a novel inhibitor of both JNK and ERK1/2, in male C57/BL6 mice given with an hyper-stimulating dose of cerulein (50 microg/kg for… (More)

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Cite this paper

@article{Minutoli2004ProtectiveEO, title={Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.}, author={Letteria Minutoli and Domenica Altavilla and Herbert Ryan Marini and Maria Passaniti and Alessandra Bitto and Paolo Seminara and F. Venuti and Ciro Famulari and Antonio Macr{\`i} and Antonino Versaci and Francesco Squadrito}, journal={Life sciences}, year={2004}, volume={75 24}, pages={2853-66} }