Protective effects of N-acetylcysteine on aluminum phosphide-induced oxidative stress in acute human poisoning.

@article{Tehrani2013ProtectiveEO,
  title={Protective effects of N-acetylcysteine on aluminum phosphide-induced oxidative stress in acute human poisoning.},
  author={Hiva Tehrani and Zahra Halvaie and Shahin Shadnia and Kambiz Soltaninejad and Mohammad Abdollahi},
  journal={Clinical toxicology},
  year={2013},
  volume={51 1},
  pages={
          23-8
        }
}
OBJECTIVE Aluminum phosphide is used as a fumigant. It produces phosphine gas (PH₃). PH₃ is a mitochondrial poison which inhibits cytochrome c oxidase, it leads to generation of reactive oxygen species; so one of the most important suggested mechanisms for its toxicity is induction of oxidative stress. In this regard, it could be proposed that a drug like N-acetylcysteine (NAC) as an antioxidant would improve the tolerance of aluminum phosphide-intoxicated cases. The objective of this study was… CONTINUE READING
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