Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice.

@article{ener2005ProtectiveEO,
  title={Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice.},
  author={G{\"o}ksel Şener and Ozer Sehirli and Şule Çetinel and Berrak G Yeğen and Nursal Gedik and G. Ayanoglu-d{\"u}lger},
  journal={Journal of applied toxicology : JAT},
  year={2005},
  volume={25 1},
  pages={20-9}
}
Acetaminophen, a widely used analgesic and antipyretic, is known to cause hepatic and renal injury in humans and experimental animals when administered in high doses. It was reported that these toxic effects of acetaminophen are due to oxidative reactions that take place during its metabolism. In this study we aimed to investigate the possible beneficial effect of 2-mercaptoethane sulphonate (MESNA), an antioxidant agent, against acetaminophen toxicity in mice. Balb-c mice were injected i.p… CONTINUE READING
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