Protective effects of KW-3635, a novel thromboxane A2 antagonist, in murine traumatic shock.

@article{Karasawa1990ProtectiveEO,
  title={Protective effects of KW-3635, a novel thromboxane A2 antagonist, in murine traumatic shock.},
  author={Aya Karasawa and Patricia A. Taylor and Allan M. Lefer},
  journal={European journal of pharmacology},
  year={1990},
  volume={182 1},
  pages={1-8}
}
Pentobarbital anesthetized rats subjected to Noble-Collip drum trauma developed a shock state characterized by marked hypotension, increases in plasma cathepsin D (9.6-fold), free amino-nitrogen (4.0-fold), and myocardial depressant factor (5.2-fold) activities, and a survival time of 1.90 +/- 0.23 h. Following the induction of traumatic shock, plasma… CONTINUE READING