Corpus ID: 6758074

Protective effects of Ginkgo biloba extract on cultured rat cardiomyocytes damaged by H2O2.

@article{Niu1999ProtectiveEO,
  title={Protective effects of Ginkgo biloba extract on cultured rat cardiomyocytes damaged by H2O2.},
  author={Y. Niu and X. Y. Yang and W. Bao},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1999},
  volume={20 7},
  pages={
          635-8
        }
}
  • Y. Niu, X. Y. Yang, W. Bao
  • Published 1 July 1999
  • Biology, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica Sinica
AIM To investigate the influence of Ginkgo biloba extract (GbE) on cardiomyocytes damaged by H2O2. METHODS Cultured rat cardiomyocytes were divided into 3 groups randomly: control group; H2O2 (2.5 mmol.L-1) group; H2O2 2.5 mmol.L-1 + GbE 150 mg.L-1 group. The cardiomyocytes were cultured in MEM (Eagle's) at 37 degrees C in the presence of 5% CO2 for 4 h. Lactate dehydrogenase (LDH) was assayed by colorimetric method. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive… Expand
Paradoxical effects of ginkgolide B on cardiomyocyte contractile function in normal and high-glucose environments
TLDR
Ginkgolide B affects cardiomyocyte contractile function under NG or HG environments in a paradoxical manner, which may be attributed to uneven action on Ca2+ regulatory proteins under NG and HG conditions. Expand
Impact of Ginkgo Biloba Extract EGb 761 on Ischemia/Reperfusion – Induced Oxidative Stress Products Formation in Rat Forebrain
TLDR
The results indicate that extract of EGb 761 has potent antioxidant activity and could play a role to attenuate the IRI-induced oxidative protein modification and lipoperoxidation in the neuroprotective process. Expand
Antihyperglycemic Effect of Ginkgo biloba Extract in Streptozotocin-Induced Diabetes in Rats
TLDR
GBE possesses antihyperglycemic, antioxidant, and antihyperlipidemia activities in STZ-induced chronic diabetic rats, which promisingly support the use of GBE as a food supplement or an adjunct treatment for diabetics. Expand
Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.
TLDR
The modulation of CYP isozymes by GbE and Tan may result in altered metabolism of coadministered drugs. Expand
Experimental evidence of Ginkgo biloba extract EGB as a neuroprotective agent in ischemia stroke rats
TLDR
Data demonstrate that EGb761 had significant therapeutic effects on ischemic stroke and it perhaps worked through activating the Akt-CREB-BDNF pathway. Expand
Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor.
TLDR
The results indicate that Ginkgolide B may significantly dampen Aβ25-35-induced apoptosis, and the neuroprotective effects may be intimately associated with brain-derived neurotrophic factor up-regulation caused by GinkGolides B. Expand
WITHDRAWN: Comprehensive evaluation of neuroprotective effects of Ginkgo biloba extract EGB against ischemic stroke.
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can beExpand