• Corpus ID: 8523971

Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage.

@article{Chen1998ProtectiveEO,
  title={Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage.},
  author={J X Chen and W Z Chen and H L Huang and L X Chen and Z Z Xie and Bo Zhu},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1998},
  volume={19 4},
  pages={
          359-63
        }
}
  • J. X. ChenW. Chen B. Zhu
  • Published 1 July 1998
  • Biology, Chemistry, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica Sinica
AIM To study the protective effects of Ginkgo biloba extract (GbE) against endothelial cell damage induced by lysophosphatidylcholine (LPC). METHODS The vasorelaxation response to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aorta. Lipid peroxidation products were determined by measuring thiobarbituric acid reactive substance. RESULTS GbE attenuated the inhibition of vasorelaxation response to ACh and prevented the LPC-induced increase of malondialdehyde (MDA… 
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18 Citations

Inhibitory effects of Ginkgo biloba extract on vascular endothelial growth factor in rat aortic endothelial cells.

GbE could protect RAEC against the LPC-induced damage and downregulate VEGF protein and V EGF mRNA expression in cultured RAEC.

Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.

Study the preventive effect of aqueous extract of Gingko biloba on cerebral damage induced by ischemia / reperfusion in rat

The present results suggest that Gingko biloba treatment protects the rat brain against ischemiareperfusion brain damage.

Heme Oxygenase, Ginkgo Biloba Extract and its Terpenoids Protect Myocytes Against Oxidative Injury

Two classes of cellular protectants, heat shock proteins (HSPs) and endogenous anti-oxidant enzymes, have been postulated to participate in this I/P induced cardioprotection.

Biological Activity of Ginkgo

The anti-ischemic neuroprotective effects of Egb have been proved in cerebral and spinal cord ischemic models in animals, the action possibly being related to a functional state of mitochondria and apoptosis but high-quality and large-scale randomized controlled trials are needed to test its efficacy for the treatment of human stroke.

Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage.

The results suggest that induction of HO-1 by Ginkgo Biloba Extract but not its terpenoid constituents may play a beneficial role in oxidative stress.

The combined effects of ginkgo biloba extracts and aspirin on viability of sk-N-mc, neuroblastoma cell line in hypoxia and reperfusion condition.

This study suggests that the combined treatments of Ginkgo biloba extracts and aspirin increase the regeneration of neuroblastoma cells injured by hypoxia and reperfusion.

Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy.

GbE could prevent and treat acute cerebral ischemia and the effectiveness was more satisfactory when GbE was used preventively.

Antioxidant compounds EGB-761 and BN-520 21 attenuate heat shock protein (HSP 72 kD) response, edema and cell changes following hyperthermic brain injury

The results show that EGB-761 and its component Gingkolide B (BN-52021) has the capacity to reduce edema and cell injury following hyperthermia and this effect of the compound is somehow associated with a reduction in cellular stress response as evidenced with a reduce in HSP expression.

Experimental evidence of Ginkgo biloba extract EGB as a neuroprotective agent in ischemia stroke rats