Corpus ID: 8523971

Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage.

@article{Chen1998ProtectiveEO,
  title={Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage.},
  author={Jiandong Chen and W Z Chen and H L Huang and L X Chen and Z Z Xie and Bing-yang Zhu},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1998},
  volume={19 4},
  pages={
          359-63
        }
}
  • J. Chen, W. Z. Chen, +3 authors B. Zhu
  • Published 1 July 1998
  • Chemistry, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica Sinica
AIM To study the protective effects of Ginkgo biloba extract (GbE) against endothelial cell damage induced by lysophosphatidylcholine (LPC). METHODS The vasorelaxation response to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aorta. Lipid peroxidation products were determined by measuring thiobarbituric acid reactive substance. RESULTS GbE attenuated the inhibition of vasorelaxation response to ACh and prevented the LPC-induced increase of malondialdehyde (MDA… Expand
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18 Citations

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Inhibitory effects of Ginkgo biloba extract on vascular endothelial growth factor in rat aortic endothelial cells.
TLDR
GbE could protect RAEC against the LPC-induced damage and downregulate VEGF protein and V EGF mRNA expression in cultured RAEC. Expand
Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.
TLDR
Selective inhibition of iNOS by EGb may be therapeutically relevant in modulating NO production in endothelial cells. Expand
Study the preventive effect of aqueous extract of Gingko biloba on cerebral damage induced by ischemia / reperfusion in rat
Background: cerebral damage may occur in a variety of clinical settings and this remains a significant problem. Therefore, it seems possible that the administration aqueous extract of Gingko biloba… Expand
Heme Oxygenase, Ginkgo Biloba Extract and its Terpenoids Protect Myocytes Against Oxidative Injury
A number of pharmacological approaches to protect against myocardial damage during ischemia reperfusion events (e.g. β-blockers, calcium antagonists, nitrates, and free radical scavengers) have met… Expand
Biological Activity of Ginkgo
The extract of Ginkgo biloba (Egb) contains more than 60 active substances with a high bioavailability. EGb has extensive protective effects on the central nervous system and cerebrovascular system.… Expand
Impact of Ginkgo Biloba Extract EGb 761 on Ischemia/Reperfusion – Induced Oxidative Stress Products Formation in Rat Forebrain
TLDR
The results indicate that extract of EGb 761 has potent antioxidant activity and could play a role to attenuate the IRI-induced oxidative protein modification and lipoperoxidation in the neuroprotective process. Expand
Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage.
TLDR
The results suggest that induction of HO-1 by Ginkgo Biloba Extract but not its terpenoid constituents may play a beneficial role in oxidative stress. Expand
The combined effects of ginkgo biloba extracts and aspirin on viability of sk-N-mc, neuroblastoma cell line in hypoxia and reperfusion condition.
TLDR
This study suggests that the combined treatments of Ginkgo biloba extracts and aspirin increase the regeneration of neuroblastoma cells injured by hypoxia and reperfusion. Expand
Effects of Ginkgo biloba extract on acute cerebral ischemia in rats analyzed by magnetic resonance spectroscopy.
TLDR
GbE could prevent and treat acute cerebral ischemia and the effectiveness was more satisfactory when GbE was used preventively. Expand
Antioxidant compounds EGB-761 and BN-520 21 attenuate heat shock protein (HSP 72 kD) response, edema and cell changes following hyperthermic brain injury
TLDR
The results show that EGB-761 and its component Gingkolide B (BN-52021) has the capacity to reduce edema and cell injury following hyperthermia and this effect of the compound is somehow associated with a reduction in cellular stress response as evidenced with a reduce in HSP expression. Expand
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