Protective effects of FCGR2A polymorphism in invasive pneumococcal diseases

  title={Protective effects of FCGR2A polymorphism in invasive pneumococcal diseases},
  author={Adrien Bougl{\'e} and Adeline Max and Nicolas Mongardon and David Grimaldi and Fr{\'e}d{\'e}ric P{\`e}ne and Christophe Rousseau and J P Chiche and J B{\'e}dos and {\'E}ric Vicaut and Jean Paul Mira},
BACKGROUND Streptococcus pneumoniae is a major cause of pneumonia and meningitis. Several genetic polymorphisms have been described to explain differences in susceptibility and severity of encapsulated pathogen-related diseases. Among them, a functional FCGR2A polymorphism leading to amino acid change of histidine (H) to arginine (R) at position 131 appears to be a major candidate in adult invasive pneumococcal diseases (IPDs). However, previous reports need confirmation in a large, well… CONTINUE READING