Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats.

@article{Zhao2009ProtectiveEO,
  title={Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats.},
  author={Wei Zhao and Feng Zhu and Weiwei Shen and Aifen Fu and L. -M. Zheng and Zhaowen Yan and Lingzi Zhao and Guo-Hui Fu},
  journal={Acta biochimica et biophysica Sinica},
  year={2009},
  volume={41 4},
  pages={
          301-8
        }
}
The compound 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) is an efficient anion exchanger inhibitor that can block the activities of anion exchanger 2 (AE2), which plays an indispensable role in gastric acid secretion. DIDS also has potent anti-oxidative and antiapoptosis activities. This study aimed to investigate the effect of DIDS on ethanol-induced mucosal damage in rats and to evaluate the underlying mechanisms that mediate the action of the compound. The rats received 1 ml of… CONTINUE READING

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