Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice.

@article{He2011ProtectiveEO,
  title={Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice.},
  author={Yue-ying He and Bao-xu Zhang and Feng-lan Jia},
  journal={World journal of gastroenterology},
  year={2011},
  volume={17 21},
  pages={2663-6}
}
AIM To examine the effects of 2,4-dihydroxybenzophenone (BP-1), a benzophenone derivative used as an ultraviolet light absorbent, on acetaminophen (APAP)-induced hepatotoxicity in C57BL/6J mice. METHODS Mice were administered orally with BP-1 at doses of 200, 400 and 800 mg/kg body weight respectively every morning for 4 d before a hepatotoxic dose of APAP (350 mg/kg body weight) was given subcutaneously. Twenty four hours after APAP intoxication, the serum enzyme including serum alaine… CONTINUE READING