Protective effects of 17beta-estradiol on post-ischemic cardiac dysfunction and norepinephrine overflow through the non-genomic estrogen receptor/nitric oxide-mediated pathway in the rat heart.

@article{Fukumoto2013ProtectiveEO,
  title={Protective effects of 17beta-estradiol on post-ischemic cardiac dysfunction and norepinephrine overflow through the non-genomic estrogen receptor/nitric oxide-mediated pathway in the rat heart.},
  author={Taiki Fukumoto and Masashi Tawa and Naoto Yamashita and Mamoru Ohkita and Yasuo Matsumura},
  journal={European journal of pharmacology},
  year={2013},
  volume={699 1-3},
  pages={74-80}
}
The present study was undertaken to examine the effect of acute treatment with 17β-estradiol on post-ischemic cardiac dysfunction and norepinephrine overflow and its possible mechanisms. Male rat hearts were perfused with the Langendorff method and subjected to 40 min of global ischemia followed by 30 min of reperfusion. Each drug was perfused from 15 min before ischemia to 5 min after reperfusion. During reperfusion, 17β-estradiol treatment showed significantly greater functional recovery of… CONTINUE READING