Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture.

@article{Ibi2001ProtectiveEO,
  title={Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture.},
  author={Masakazu Ibi and Hideyuki Sawada and Miki Nakanishi and Toshiaki Kume and H. Katsuki and Shuji Kaneko and Shun Shimohama and Akinori Akaike},
  journal={Neuropharmacology},
  year={2001},
  volume={40 6},
  pages={761-71}
}
This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in both dopaminergic and non-dopaminergic neurons. Pretreatment, but not co-administration, of 1 alpha,25-(OH)(2)D(3) protected both types of neurons against the cytotoxicity of… CONTINUE READING
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