Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.

  title={Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.},
  author={Christoph Dorn and Joerg Heilmann and Claus Hellerbrand},
  journal={International journal of clinical and experimental pathology},
  volume={5 1},
Xanthohumol, the major prenylated chalcone found in hops, is known for its anti-inflammatory properties. We have recently shown that xanthohumol inhibits hepatic inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis. The aim of this study was to investigate the effect of xanthohumol in an acute model of liver injury. Carbon tetrachloride (CCl(4)), an industrial solvent, is a hepatotoxic agent and its administration is widely used as an animal model of toxin-induced liver… CONTINUE READING
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