Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.

@article{Kosakai1991ProtectiveEO,
  title={Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.},
  author={Y Kosakai and Toshiharu Horie and Shoji Awazu},
  journal={Pharmacology \& toxicology},
  year={1991},
  volume={69 4},
  pages={
          291-5
        }
}
Vitamin A (VA) protects the small intestine from the methotrexate (MTX)-induced damage. The in vivo effects of MTX and/or VA on crypt cells of small intestine were investigated using rats orally administered MTX (15 mg/kg body weight) and/or VA (5,000 IU/kg body weight). The thymidine kinase activity of crypt cells separated from villus cells of small intestine of MTX plus VA-treated rats was lower than that from control rats but higher than that from MTX-treated rats. VA-treated rats showed… 
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References

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It has been shown histologically, biochemically, physicochemical, physicochemically and physiologically that VA protects the small intestine from the damage induced by MTX.
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TLDR
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