Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.

@article{Kosakai1991ProtectiveEO,
  title={Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.},
  author={Y. Kosakai and T. Horie and S. Awazu},
  journal={Pharmacology & toxicology},
  year={1991},
  volume={69 4},
  pages={
          291-5
        }
}
  • Y. Kosakai, T. Horie, S. Awazu
  • Published 1991
  • Chemistry, Medicine
  • Pharmacology & toxicology
  • Vitamin A (VA) protects the small intestine from the methotrexate (MTX)-induced damage. The in vivo effects of MTX and/or VA on crypt cells of small intestine were investigated using rats orally administered MTX (15 mg/kg body weight) and/or VA (5,000 IU/kg body weight). The thymidine kinase activity of crypt cells separated from villus cells of small intestine of MTX plus VA-treated rats was lower than that from control rats but higher than that from MTX-treated rats. VA-treated rats showed… CONTINUE READING
    Amelioration of methotrexate-induced malabsorption by vitamin A
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