Protective effect of vaccination with Toxoplasma lysate antigen and CpG as an adjuvant against Toxoplasma gondii in susceptible C57BL/6 mice.

@article{ElMalky2005ProtectiveEO,
  title={Protective effect of vaccination with Toxoplasma lysate antigen and CpG as an adjuvant against Toxoplasma gondii in susceptible C57BL/6 mice.},
  author={Mohamed M El-Malky and Lu Shaohong and Takashi Kumagai and Yoshisada Yabu and Mohamed S Noureldin and Niveen Saudy and Haruhiko Maruyama and Nobuo Ohta},
  journal={Microbiology and immunology},
  year={2005},
  volume={49 7},
  pages={639-46}
}
Infection with the intracellular protozoan parasite Toxoplasma gondii causes serious public health problems to both humans and livestock and of great economic impact worldwide. Oligodeoxynucleotides (ODN) which contain immunostimulatory CG motifs (CpG ODN) can promote Th1 responses, an adjuvant activity that is desirable for vaccination against intracellular pathogens. We investigated the feasibility of using CpG as an adjuvant combined with Toxoplasma lysate antigen (TLA) as a vaccine against… CONTINUE READING
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