Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.

Abstract

(2S,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As a neuroprotective agent, DCG-IV was much… (More)

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@article{Bruno1994ProtectiveEO, title={Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.}, author={V. Bruno and Agata Copani and Giorgio Battaglia and Rennan Raffaele and Haruna Shinozaki and Ferdinando Nicoletti}, journal={European journal of pharmacology}, year={1994}, volume={256 1}, pages={109-12} }