Protective effect of tetrandrine on doxorubicin-induced cardiotoxicity in rats.

  title={Protective effect of tetrandrine on doxorubicin-induced cardiotoxicity in rats.},
  author={Meng Xu and Lianghe Sheng and Xinhai Zhu and Shibin Zeng and Dexiang Chi and Guojun Zhang},
  volume={96 3},
AIMS AND BACKGROUND Doxorubicin (Dox) is effective in curative and adjuvant chemotherapy of malignant tumors. Cardiotoxicity is the chief toxic effect that limits the clinical use of Dox. We studied the effects of tetrandrine (Tet) on doxorubicin-induced cardiotoxicity in rats and its protective activity. MATERIALS AND METHODS Sprague-Dawley rats were randomly divided into the following 4 groups: a control group (received only saline), Dox group (received only Dox), Tet/Dox group (received… CONTINUE READING


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