Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury.

@article{Zhao2016ProtectiveEO,
  title={Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury.},
  author={Jiping Zhao and Hao Yu and Yudong Liu and Sara A. Gibson and Zhaoqi Yan and Xin Xu and Amit Gaggar and Pui-kai Li and Chenglong Li and Shi Gao Wei and Etty Nadia Benveniste and Hongwei Qin},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2016},
  volume={311 5},
  pages={L868-L880}
}
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with high mortality. Macrophages and neutrophils are responsible for inflammatory responses in ALI and ARDS, which are characterized by excessive production of proinflammatory mediators in bronchoalveolar lavage fluid (BALF) and plasma. Aberrant activation of the JAK/STAT pathway is critical for persistent inflammation in many conditions such as infection and autoimmunity. Given the importance of the STAT3… CONTINUE READING

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