Protective effect of sulfinpyrazone against catecholamine metabolite adrenochrome-induced arrhythmias.

@article{Beamish1981ProtectiveEO,
  title={Protective effect of sulfinpyrazone against catecholamine metabolite adrenochrome-induced arrhythmias.},
  author={Robert E. Beamish and Kulbir Dhillon and Pawan K. Singal and Naranjan S. Dhalla},
  journal={American heart journal},
  year={1981},
  volume={102 2},
  pages={149-52}
}
Single intravenous injection of adrenochrome (10 to 50 mg/kg body weight), an oxidation product of catecholamines, has been shown to induce arrhythmias and cause death in anesthetized rats in a dose-dependent manner. Sulfinpyrazone, which is an inhibitor of platelet aggregation, was found to protect animals from these adrenochrome effects. It is suggested… CONTINUE READING