• Corpus ID: 24456519

Protective effect of spermatogenic activity of Withania Somnifera (Ashwagandha) in galactose stressed mice

@article{Patil2012ProtectiveEO,
  title={Protective effect of spermatogenic activity of Withania Somnifera (Ashwagandha) in galactose stressed mice},
  author={Rahul B. Patil and Shreya R Vora and Meena M Pillai},
  journal={Annals of Biological Research},
  year={2012},
  volume={3},
  pages={4159-4165}
}
In recent years, population is facing many health problems like chronic non-communicable diseases like Cancer, Stroke, Diabetes, Cardiovascular disorders and Reproductive disorders fro very early age. Urbanization and mechanization have changed the life style of the whole population which has resulted in greater exposure to pollution, high consumption of salt and fat containing food, low physical activity and stress. Withania may be having antioxidant property; protecting male reproductive… 

Figures from this paper

SPERMATOGENIC ACTIVITY OF ISAPPUKOL CHOORANAM (SIDDHA DRUG) AGAINST TCDD INDUCED OLIGOSPERMIC RATS
TLDR
Isappukol chooranam have increased spermatogenesis of adult male rats and it can be used more effectively in the treatment of Oligospermia and male infertility.
Efficacy of Ashwagandha (Withania somnifera L.) root extracts in preventing stress induced testicular damagein rat
TLDR
The results indicate that stress alters testicular activity by suppressing the testicular steroidogenic activity and causing oxidative damage, which are effectively prevented by root extracts of Ashwagandha by suppressing stress induced activation of the hypothalamus-pituitary-adrenal axis.
Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats
TLDR
There was significant reversal in the parameters denoting that Withania somnifera possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it.
Effects of Withania coagulans extract and morphine on spermatogenesis in rats
TLDR
The results show that the higher dose of Withania coagolans extract exerts varying effects on reproductive parameters, while the lower dose enhanced spermatogenesis while also protecting against the damaging effects of morphine.
Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats
TLDR
Data accrued suggest the potential of Withania somnifera root extract to improve diabetes-induced testicular dysfunctions in prepubertal rats.
WITHANIA SOMNIFERA PROTECTS THE HAEMATOLOGICAL ALTERATIONS CAUSED BY SODIUM ARSENITE IN CHARLES FOSTER RATS
TLDR
The study reveals that ethanolic extract of Withania somnifera possesses protective effect against haematological alterations caused by arsenic induced toxicity.
Is the use of plants in Jordanian folk medicine for the treatment of male sexual dysfunction scientifically based? Review of in vitro and in vivo human and animal studies
TLDR
Many plants used in Jordanian folk medicine decreased or had no effect on spermatogenesis in animal models, and these plants have antioxidant and/or adaptogenic effects, and this may result in a beneficial action on male reproductive system.
Acute and Sub Acute Toxicity Study on Siddha Drug Thennangal Thiravagam
TLDR
TT was found to be safe in animals and no toxic effect was observed upto 650 µl/kg in both acute and sub-acute toxicity studies.
Effects of Exendin-4 on Male Reproductive Parameters of D-Galactose Induced Aging Mouse Model
TLDR
D-galactose can induce aging alternations in the male reproductive system such as decreased sperm count and increased serum LH and FSH levels through reactive oxygen species over production and reduced antioxidant enzyme activity.
Delayed response of epididymal sperm characteristics and testicular oxidative stress following EGME exposure: Ameliorating potential of Withania somnifera root extract -
TLDR
The study suggested that the toxicity of EGME noticed during early treatment withdrawal period, may be prevented by Ws root extract therapy.
...
...

References

SHOWING 1-9 OF 9 REFERENCES
"J."
however (for it was the literal soul of the life of the Redeemer, John xv. io), is the peculiar token of fellowship with the Redeemer. That love to God (what is meant here is not God’s love to men)
Adv
  • Biol. Res .
  • 2010
Fertil
  • Steril.
  • 1979
Mech
  • Ageing Dev .
  • 1999
C
  • W Hutchison and P. J. Nathan, Psychopharmacol.
  • 2002
Vaidyaratnam and Varier's, (In Med. Plants, A Compendium of 500 species
  • 1994
Vaidyaratnam and Varier’s
  • (In Med. Plan ts, A Compendium of 500 species,
  • 1994
Eur
  • J. Nutr.
  • 1999
C
  • Kandaswami and T.C. Theohar ides, Pharmacol. Rev .
  • 2000