Protective effect of simvastatin on impaired intestine tight junction protein ZO-1 in a mouse model of Parkinson’s disease

@article{XinFang2015ProtectiveEO,
  title={Protective effect of simvastatin on impaired intestine tight junction protein ZO-1 in a mouse model of Parkinson’s disease},
  author={鑫 XinFang方 and Ren-shi Xu 徐仁伵},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  year={2015},
  volume={35},
  pages={880-884}
}
Recently, several studies showed that gastrointestinal tract may be associated with pathophysiology of Parkinson’s disease (PD). Intestine tight junction protein zonula occluden-1 (ZO-1) is an important component of intestinal barrier which can be degraded by matrix metallopeptidase 9 (MMP-9). In our previous study, a significant decline in ZO-1 was observed along with enhanced MMP-9 activity in the duodenum and distal colon of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated… CONTINUE READING

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