Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice.

@article{Kumazawa1990ProtectiveEO,
  title={Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice.},
  author={Yoshio Kumazawa and Takuya Kawakita and Hiroaki Takimoto and Ken'ichi Nomoto},
  journal={International journal of immunopharmacology},
  year={1990},
  volume={12 5},
  pages={
          531-7
        }
}
Effects of saikosaponins and their genins on nonspecific resistance against Pseudomonas aeruginosa and Listeria monocytogenes infections were investigated. When mice were administered intraperitoneally (i.p.) saikosaponins one day before i.p. infection with P. aeruginosa, saikosaponins a and d induced a marked enhancement of nonspecific resistance at a dose of 10 micrograms/mouse. Also, saikogenin D, a secondary metabolite of saikosaponin d, showed an enhancing effect. The most effective… CONTINUE READING

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