Corpus ID: 3961712

Protective effect of resveratrol against methotrexate-induced oxidative stress in the small intestinal tissues of rats.

@article{Arslan2015ProtectiveEO,
  title={Protective effect of resveratrol against methotrexate-induced oxidative stress in the small intestinal tissues of rats.},
  author={Aynur Arslan and Fatih Ozcicek and Ferda Keskin Çimen and Durdu Altuner and Oğuzhan Yaralı and Nezahat Kurt and Levent Tumkaya and Cengiz Ozturk and Halis Suleyman},
  journal={International journal of clinical and experimental medicine},
  year={2015},
  volume={8 7},
  pages={
          10491-500
        }
}
The effect of resveratrol on the damage induced by methotrexate (MTX) in rat duodenum and jejunum tissue was investigated and evaluated in comparison with famotidine. The rats were divided into four groups as healthy group (HG), resveratrol+MTX (RMTX) group, famotidine+MTX (FMTX) group and the control group which received MTX (MTXC). RMTX group was given resveratrol 25 mg/kg and FMTX group famotidin 25 mg/kg, while MTXC and HG groups were orally administered distilled water once a day for 30… Expand
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Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation
TLDR
RVT treatment significantly prevented MTX-induced hepatotoxicity, as indicated by AST, ALT, and ALP levels and liver histopathology, and revealed that RVT may have a protective effect against methotrexate (MTX) therapy by inhibiting oxidative stress-mediated lipid peroxidation. Expand
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The present study suggests that melatonin may be of therapeutic benefit when used with MTX and elucidates the role of free radicals in MTX‐induced toxicity and the protection by melatonin. Expand
Resveratrol protects against methotrexate-induced hepatic injury in rats.
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TLDR
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TLDR
In conclusion, mirtazapine can be used to prevent infertility appearing in patients receiving MTX therapy and an association between oxidative stress in ovarian tissue induced by MTX and infertility is demonstrated. Expand
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TLDR
The results of the present study demonstrate that supplementation by exogenous melatonin significantly reduces MTX-induced small intestinal damage, indicating that it may be beneficial in ameliorating MTx-induced enteritis in humans. Expand
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TLDR
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