Protective effect of neutrophil elastase inhibitor (FR136706) in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.

@article{Uchida2008ProtectiveEO,
  title={Protective effect of neutrophil elastase inhibitor (FR136706) in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.},
  author={Yoichiro Uchida and Masaki Kaibori and Takeshi Hijikawa and Morihiko Ishizaki and Takashi Ozaki and Hironori Tanaka and Kosuke Matsui and Katsuji Tokuhara and A-hon Kwon and Yasuo Kamiyama and Tadayoshi Okumura},
  journal={The Journal of surgical research},
  year={2008},
  volume={145 1},
  pages={57-65}
}
BACKGROUND/AIMS It has been reported that liver dysfunction with ischemia-reperfusion is improved through selective inhibition of neutrophil elastase (NE) by NE inhibitor. This study was designed to investigate whether NE inhibitor has protective effect in lethal acute liver failure. MATERIALS AND METHODS Rats were treated with D-galactosamine plus lipopolysaccharide (GalN/LPS) to induce acute liver failure. NE inhibitor (FR136706) was administered intravenously before GalN/LPS injection… CONTINUE READING