Protective effect of naturally occurring anti-HER2 autoantibodies on breast cancer

@article{Tabuchi2016ProtectiveEO,
  title={Protective effect of naturally occurring anti-HER2 autoantibodies on breast cancer},
  author={Yukiko Tabuchi and Masafumi Shimoda and Naofumi Kagara and Yasuto Naoi and Tomonori Tanei and Atsushi Shimomura and Kenzo Shimazu and Seung Jin Kim and Shinzaburo Noguchi},
  journal={Breast Cancer Research and Treatment},
  year={2016},
  volume={157},
  pages={55-63}
}
Anti-HER2-autoantibodies (HER2-AAbs) are found in breast cancer patients as well as healthy individuals. However, the clinical relevance of the antibodies is unknown. We established an enzyme-linked immunosorbent assay with high sensitivity and quantified serum HER2-AAbs in 100 healthy women, 100 untreated patients with ductal carcinoma in situ (DCIS), and 500 untreated patients with invasive breast carcinoma (IBC). The associations between the levels of HER2-AAbs and breast cancer risk, and… CONTINUE READING