Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice.

@article{Dhir2006ProtectiveEO,
  title={Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice.},
  author={Ashish Dhir and Satyanarayana S. V. Padi and P. S. Naidu and Shrinivas Krishnarao Kulkarni},
  journal={European journal of pharmacology},
  year={2006},
  volume={535 1-3},
  pages={192-8}
}
Chronic stress precipitates many neuropsychiatric disorders and alters the various oxidative stress parameters in brain. Cyclooxygenase (COX) is reported to play an important role in pathogenesis of various neurodegenerative disorders including stroke and seizures. In the present study, we examined the effect of naproxen (non-selective COX-inhibitor having much potency towards COX-I isoform) or rofecoxib (a selective COX-2 inhibitor) in subchronic immobilization stress. Mice were subjected to… CONTINUE READING
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