Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats.

@article{Bilginolu2014ProtectiveEO,
  title={Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats.},
  author={Ayça Bilginoğlu and Duygu Aydın and Seyma Ozsoy and Hatice Banu Ayg{\"u}n},
  journal={Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir},
  year={2014},
  volume={42 3},
  pages={265-73}
}
OBJECTIVES Adriamycin is one of the most widely used anticancer drugs. The major limiting factor of using this drug is the development of cardiotoxicity. However, melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous molecule as a good antioxidant that may protect the heart. We investigated whether or not pretreatment with melatonin can attenuate adriamycin-induced cardiotoxicity. STUDY DESIGN All procedures and experiments were approved by the Animal Ethics Committee of Gazi Osman Paşa… CONTINUE READING