Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways

@article{Suchal2017ProtectiveEO,
  title={Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways},
  author={Kapil Suchal and Salma Malik and S. Khan and R. Malhotra and S. Goyal and J. Bhatia and S. Kumari and S. Ojha and D. Arya},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
  • Kapil Suchal, Salma Malik, +6 authors D. Arya
  • Published 2017
  • Medicine
  • Scientific Reports
    • Hyperglycemia induced advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) activation is thought to involve in the development of cardiovascular disease in diabetics. Activation of AGE-RAGE axis results in the oxidative stress and inflammation. Mangiferin is found in the bark of mango tree and is known to treat diseases owing to its various biological activities. Thus, this study was designed to evaluate the effect of mangiferin in ischemia-reperfusion (IR… CONTINUE READING
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    References

    SHOWING 1-10 OF 54 REFERENCES
    Mangiferin protect myocardial insults through modulation of MAPK/TGF-β pathways.
    • 26
    Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats.
    • 188
    Protective effects of mangiferin on cerebral ischemia-reperfusion injury and its mechanisms.
    • 47
    Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats.
    • 53
    Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNFα Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin-Induced Diabetic Rats
    • 120
    • PDF
    Mangiferin suppressed advanced glycation end products (AGEs) through NF-κB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats.
    • 49
    Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects
    • 49
    Receptor for Advanced-Glycation End Products: Key Modulator of Myocardial Ischemic Injury
    • 222
    • PDF
    Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats.
    • 353
    • PDF
    Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats
    • 59
    • PDF