Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways

@article{Suchal2017ProtectiveEO,
  title={Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways},
  author={Kapil Suchal and Salma Malik and S. Khan and R. Malhotra and S. Goyal and J. Bhatia and S. Kumari and S. Ojha and D. Arya},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
  • Kapil Suchal, Salma Malik, +6 authors D. Arya
  • Published 2017
  • Medicine
  • Scientific Reports
  • Hyperglycemia induced advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) activation is thought to involve in the development of cardiovascular disease in diabetics. Activation of AGE-RAGE axis results in the oxidative stress and inflammation. Mangiferin is found in the bark of mango tree and is known to treat diseases owing to its various biological activities. Thus, this study was designed to evaluate the effect of mangiferin in ischemia-reperfusion (IR… CONTINUE READING
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