Protective effect of long-term angiotensin II inhibition.

  title={Protective effect of long-term angiotensin II inhibition.},
  author={Nidia Basso and Rosa Cini and Adriana Pietrelli and Le{\'o}n F. Ferder and Norberto Antonio Terragno and Felipe Inserra},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={293 3},
Experimental studies indicate that angiotensin II (ANG II) through its type 1 receptor (AT(1)) promotes cardiovascular hypertrophy and fibrosis. Therefore, the aim of this study was to analyze whether chronic long-term inhibition of the renin-angiotensin system (RAS) can prevent most of the deleterious effects due to aging in the cardiovascular system of the normal rat. The main objective was to compare two strategies of ANG II blockade: a converting enzyme inhibitor (CEI) and an AT(1) receptor… CONTINUE READING
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