Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells.

@article{MiticCulafic2009ProtectiveEO,
  title={Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells.},
  author={Dragana Mitic-Culafic and Bojana Žegura and Biljana M Nikoli{\'c} and Branka Vukovi{\'c}-Ga{\vc}i{\'c} and Jelena Kne{\vz}evi{\'c}-Vuk{\vc}evi{\'c} and Metka Filipi{\vc}},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2009},
  volume={47 1},
  pages={260-6}
}
We studied the protective effect of monoterpenes myrcene, eucalyptol and linalool against t-butyl hydroperoxide (t-BOOH) induced genotoxicity in reverse mutation assay with Escherichia coli WP2 IC185 strain and its oxyR mutant IC202, and with the comet assay in human hepatoma HepG2 and human B lymphoid NC-NC cells. The monoterpenes were tested in concentration ranges 0.05-1.5 mg/plate and 0.01-1.0 microg/ml in bacteria and mammalian cells, respectively. Suppression of t-BOOH induced mutagenesis… CONTINUE READING
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