Protective effect of lafutidine against indomethacin-induced intestinal ulceration in rats: relation to capsaicin-sensitive sensory neurons.

@article{Kato2000ProtectiveEO,
  title={Protective effect of lafutidine against indomethacin-induced intestinal ulceration in rats: relation to capsaicin-sensitive sensory neurons.},
  author={Shinichi Kato and Araki Tanaka and Tomonori Kunikata and Masakazu Umeda and Koji Takeuchi},
  journal={Digestion},
  year={2000},
  volume={61 1},
  pages={
          39-46
        }
}
BACKGROUND/AIM We examined the prophylactic effect of lafutidine, a novel histamine H(2)-receptor antagonist [(+/-)-2-(furfurylsulfinyl)-N-[4-[4-(piperidinomethyl)-2-pyr idyl]oxy- (Z)-2 butenyl]acetamide], on indomethacin-induced small intestinal ulcers in rats and investigated the relation of this action to capsaicin-sensitive sensory neurons. METHODS AND RESULTS Subcutaneously administered indomethacin (10 mg/kg) provoked ulceration in the small intestine, mainly the jejunum and ileum… CONTINUE READING

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