• Corpus ID: 29272497

Protective effect of inositol hexaphosphate against UVB damage in HaCaT cells and skin carcinogenesis in SKH1 hairless mice.

  title={Protective effect of inositol hexaphosphate against UVB damage in HaCaT cells and skin carcinogenesis in SKH1 hairless mice.},
  author={Kendra A. Williams and Krishnan Kolappaswamy and Louis J Detolla and Ivana Vucenik},
  journal={Comparative medicine},
  volume={61 1},
UVB radiation damages keratinocytes, potentially inducing chronic skin damage, cutaneous malignancy, and suppression of the immune system. [] Key Method We assessed the protective effects of IP6 against UVB irradiationinduced injury and photocarcinogenesis by using HaCaT cells (human immortalized keratinocytes) and SKH1 hairless mice. We found that IP6 counteracts the harmful effects of UVB irradiation and increases the viability and survival of UVB-exposed cells. Treatment with IP6 after UVB irradiation (30…

Figures from this paper

Protective effect of Vaccinium myrtillus extract against UVA- and UVB-induced damage in a human keratinocyte cell line (HaCaT cells).

  • R. CalòL. Marabini
  • Chemistry, Medicine
    Journal of photochemistry and photobiology. B, Biology
  • 2014

Protective Effect of Processed Panax ginseng, Sun Ginseng on UVB-irradiated Human Skin Keratinocyte and Human Dermal Fibroblast

SG can be a potential agent that may protect against the dermal cell damage caused by UVB, and may have anti-aging property in terms of induction of procollagen gene expression and inhibition of the matrix metalloprotease-1 gene expression caused byUVBexposure.

Protection from UVB Toxicity in Human Keratinocytes by Thailand Native Herbs Extracts

These extracts stimulated the synthesis of Thioredoxin 1, an antioxidant protein, and could protect human HaCaT keratinocytes from UV‐induced DNA damage and cytotoxicity and support the utilization of turmeric and ginger extracts in anti‐UV cosmetic pharmaceuticals.

UVB-Shielding Effects of para-Coumaric Acid

It is suggested that PCA may prevent not only dyspigmentation but also inflammatory reactions in the UVB-exposed skin.

Cytotoxic effect of inositol hexaphosphate and its Ni(II) complex on human acute leukemia Jurkat T cells.

Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application

Multiple human health-beneficial effects have been related to highly phosphorylated inositol hexaphosphate (IP6). This naturally occurring carbohydrate and its parent compound, myo-inositol (Ins),

Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview.

  • I. Vucenik
  • Biology, Medicine
    Journal of nutritional science and vitaminology
  • 2019
Very few clinical studies in humans and case reports have indicated that IP6 is able to enhance the anticancer effect of conventional chemotherapy, control cancer metastases, and improve quality of life.



Naringenin Protects HaCaT Human Keratinocytes Against UVB‐induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome †

Many naturally occurring agents are believed to protect against UV‐induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on

Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes.

The dual efficacy of silibinin in protecting or enhancing UVB-caused apoptosis in the same cellular system is demonstrated and it is suggested that silib inin possibly works as a UVB damage sensor to exert its biological action.

Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures.

The results suggest that enhancement of UVB-induced apoptosis by apigenin treatment involves both the intrinsic and extrinsic apoptotic pathways.

Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin

The data suggested that the antiproliferative effects of resveratrol might be mediated via modulation in the expression and function of cell cycle regulatory proteins cyclin-D1 and -D2, cdk-2, -4 and -6, and WAF1/p21, and the modulation of cki–cyclin–cdk network by resver atrol may be associated with inhibition of the MAPK pathway.

Suppression of DMBA-Induced Mouse Skin Tumor Development by Inositol Hexaphosphate and Its Mode of Action

It seems that IP6 is an effective and potential chemopreventive agent for management of skin tumorigenesis and exerts its tumor inhibitory effect probably by modulating proliferation, differentiation, or apoptosis.

Inositol hexaphosphate induces apoptosis by coordinative modulation of P53, Bcl-2 and sequential activation of caspases in 7,12 dimethylbenz[a]anthracene exposed mouse epidermis.

  • Jaya SinghK. Gupta
  • Biology
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • 2008
It is suggested that topically applied IP6 directly induces apoptotic machinery by modulating the expression of mt p53, Bcl-2, and caspase activity, as well as the function of its dose and the duration of its exposure.

Photochemoprevention of UVB‐induced skin carcinogenesis in SKH‐1 mice by brown algae polyphenols

Observations show that brown algae polyphenols have an antiphotocarcinogenic effect which may be associated with the prevention of UVB‐induced oxidative stress, inflammation, and cell proliferation in the skin.