Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway.

@article{Tiong2010ProtectiveEO,
  title={Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway.},
  author={Chi Xin Tiong and Ming Lu and Jin-Song Bian},
  journal={British journal of pharmacology},
  year={2010},
  volume={161 2},
  pages={467-80}
}
BACKGROUND AND PURPOSE Hydrogen sulphide (H(2)S) is a novel neuromodulator. The present study aimed to investigate the protective effect of H(2)S against cell injury induced by 6-hydroxydopamine (6-OHDA), a selective dopaminergic neurotoxin often used to establish a model of Parkinson's disease for studying the underlying mechanisms of this condition. EXPERIMENTAL APPROACH Cell viability in SH-SY5Y cells was measured using MTT assay. Western blot analysis and pharmacological manipulation were… CONTINUE READING

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