Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries.

@article{Meng2007ProtectiveEO,
  title={Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries.},
  author={Qing H Meng and Guangdong Yang and Wei Yang and Bo Jiang and Ling-Yun Wu and Rui Wang},
  journal={The American journal of pathology},
  year={2007},
  volume={170 4},
  pages={1406-14}
}
Endogenous hydrogen sulfide (H(2)S), generated from homocysteine metabolism mainly catalyzed by cystathionine gamma-lyase (CSE), possesses important functions in the cardiovascular system. In this study, we investigated the role of H(2)S during the pathogenesis of neointimal formation induced by balloon injury in rats. CSE mRNA levels were reduced by 86.5% at 1 week and 64.0% at 4 weeks after balloon injury compared with the uninjured controls. CSE activity was also correspondingly reduced… CONTINUE READING

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