• Corpus ID: 23617758

Protective effect of halothane anesthesia on retinal light damage: inhibition of metabolic rhodopsin regeneration.

  title={Protective effect of halothane anesthesia on retinal light damage: inhibition of metabolic rhodopsin regeneration.},
  author={Caroline Gubser Keller and Christian Grimm and Andreas Wenzel and Farhad Hafezi and Charlotte E. Remé},
  journal={Investigative ophthalmology \& visual science},
  volume={42 2},
PURPOSE To determine whether the volatile anesthetic halothane protects against light-induced photoreceptor degeneration in the rodent retina. METHODS Albino mice and rats were anesthetized with halothane and exposed to high levels of white or blue light. Nonanesthetized animals served as controls. Retinal morphology was assessed by light microscopy, and apoptosis of photoreceptor cells was verified by detection of fragmented genomic DNA and in situ staining of apoptotic nuclei (TUNEL assay… 

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