Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells.

@article{Yim2007ProtectiveEO,
  title={Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells.},
  author={Soo Bin Yim and Sang E Park and Chung Soo Lee},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={321 2},
  pages={816-22}
}
Defects in mitochondrial function have been shown to participate in the induction of neuronal cell injury. The aim of the present study was to assess the preventive effect of licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid against the toxicity of parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP+) in relation to the mitochondria-mediated cell death process and role of oxidative stress. MPP+ induced the nuclear damage, the changes in the mitochondrial membrane permeability… CONTINUE READING

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